Role of Procalcitonin in the Early Diagnosis of Neonatal Sepsis
نویسندگان
چکیده
Objectives: To evaluate the specificity of Procalcitonin (ProCT) as marker of neonatal infection. Materials and Methods: The study includes 131 newborns admitted to the NICU. ProCT was determined in 5 groups of newborn with Sepsis, Asphyxia, Respiratory Distress Syndrome (RDS), Localized Infection and in uninfected patients. Results: Serum ProCT values were significatively high in sepsis group vs control group (p <0.002). ProCT levels correlate with the severity of Sepsis (p <0.002). Conclusions: In neonatal period, monitoring of PCT allows a rapid diagnosis of infection and is most valuable for evaluating treatment efficacy and prognosis.
منابع مشابه
Significance of Serum Procalcitonin Level in the Early Diagnosis of Neonatal Sepsis
Background: Sepsis in neonates presents itself with non-specific clinical features which makes early diagnosis difficult. However, procalcitonin (PCT) and other inflammatory markers have recently been considered as sensitive markers for the early detection of neonatal sepsis. Therefore, the present study aimed to determine the diagnostic value of PCT in the early detection of neonatal sepsis an...
متن کاملProcalcitonin: A Reliable Marker for the Diagnosis of Neonatal Sepsis
Objective(s) In the last few years, serum procalcitonin has been proposed as an early marker of infections in neonates, with varying results. In this study, we aimed to investigate the value of procalcitonin, and C- reactive protein in establishing the diagnosis of neonatal sepsis. Materials and Methods Blood samples were collected at admission from 69 neonates with suspected infection (admi...
متن کاملProcalcitonin as a Marker of Neonatal Sepsis in Intensive Care Units
Background: The appropriateness of using serum levels of procalcotonin (PCT) for early diagnosis of newborn sepsis is still controversial. Therefore, the objective of the present study was to compare the usefulness of PCT with those of serum levels of C-reactive protein (CRP) and white blood cell (WBC) counts in the diagnosis and response to treatment of neonatal sepsis. Methods: A total of 47 ...
متن کاملSensitivity And Specificity Of Procalcitonin In Diagnosis Of Neonatal Sepsis
Background and Objective: According to the fact that neonatal infection is a challenging diagnosis field, several studies have tried to test sensitivity and specificity of diagnostic tests. This study was conducted to evaluate the sensitivity and specificity of procalcitonin (PCT) as a single early marker of neonatal sepsis. Materials and Methods: In this study, 150 neonates admitted to NIC...
متن کاملNeonatal Sepsis: An Update
Sepsis is the most common cause of neonatal mortality. As per National Neonatal-Perinatal Database (NNPD), 2002-2003, the incidence of neonatal sepsis in India was 30 per 1000 live births. Signs and symptoms of sepsis are nonspecific; therefore empirical antimicrobial therapy is promptly initiated after obtaining appropriate cultures. The early manifestations of neonatal sepsis are vague and il...
متن کاملThe Relationship between Thyroid Hormones and Procalcitonin with Neonatal Sepsis: A Case Control Study in Iran, 2017
Background and Objective: Neonatal sepsis (NS) is a major cause of mortality and morbidity in neonates. Correct and early diagnosis of NS can prevent its complications. The aim of this study was to investigate the relationship between the levels of thyroid hormones and procalcitonin (PCT) with NS. Materials and Methods: In this case control study, 40 term neonates with proven NS diagnosis and ...
متن کامل